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Duplex loading with modern propellents is quite unpredictable. Blackpowder works fine as all loads are over 100% density. Do it with less and the unknown mixing will introduce another variable in the mix, something contrary to common ballistics sense.
IMHO, WC852 is too slow for the case volume of a .45-70. I'm recommending you check out Lyman's complete reloading manual as there is a wealth of loading info for this cartridge tailored for the various actions. It includes black powder duplex loading as well as the Dacron filler applications.
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