Several years back I pick up a Redhawk in 45 Colt. Since we were doing a lot of hog control at the time I was anxious to get it up and running. I tried several weight bullets up to 300gr but settled on a 280gr cast from an Accurate mold.
45-280C I went with the Linebaugh load using HS-6 and poured them with a 1-3-96 alloy. They're plenty for anything cruising our woods. They are hard enough to penetrate a 240-260'ish pound boar lengthwise from shoulder to ham, and still give some expansion. They run right at 1100fps out of the 7½" barrel and hit with plenty of authority.
After quite a bit of testing and hunting with them, they have become my go to bullets. If I need more I'll bump up to the 454.