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A 30-06 loaded with heavy 200-220 gr Nolser Partitions has proven to be just as good if not better than anything else up to one of the 375 magnums. The various 300 magnums do no better, nor worse. With good bullets, and careful shot placement rounds like 270 or 308 will kill one just as dead, but they leave little margin for error.
If a 30-06 or 300 magnum were the largest gun I owned, and if I had a chance to hunt I'd load it with the best bullets I could find and go hunting. If I were buying a gun specifically for large bear it would be a 375 magnum. Wouldn't fool with anything in between.
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