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As far as a .45, I don't really see the need to use a +p round for any reason. There is plenty of power there to spare.
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Considering all pistol calibers are extremely anemic there really isn't "power there to spare". Plus p rounds have a place in self defense with a handgun. Often the little extra velocity equals the difference between expansion of the bullet and it essentially remaining a FMJ with a hole in it.
The 45 ACP 165grain JHP +P from CorBon is cooking at 1250 FPS. It turns a round which is known for being slow and big into one that is competitive with the 40 and 357 offerings. Fast and big is better than slow and big IMO.