I would assume the OP wants to reload .303 British in order to be able to shoot his .303 British. No mention of other guns was made, so perhaps he doesn't have any, and the .303 he has is where he is going to start.
The .303 has more "quirks" than many other rounds, but it is something one can learn to do easily enough.
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All else being equal (and it almost never is) bigger bullets tend to work better.
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