Most useful for what? If you've got a horde of thousands of zombies shuffling forth, obviously a supressed .22 isn't the best tool...in situations like that you probably want a battery of 105mm howitzers...or lots of claymores.
For general security uses...well, indoors, I'd go with shorty shotguns. That Serbu Super Shorty is a cute little fella...now I kinda want one...
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