308 Loader,
You'll find one nice thing about the old 45 Auto is it can be made to run on a lot of powders. Shotgun powders like Red Dot and Unique, Clays and Universal (note: the plant where the Clays line was made is now decommissioned and the new one isn't going to produce the exact same powders, so these will be replaced with new formulations) all work well. HS-6 is slow and works best at near max loads.
With lead bullet loads, I recommend seating out to headspace on the bullet rather than on the case mouth. This has cut group size as much as 40% for me, and it reduces leading significantly. (Third from left, below. Note that some bullet shapes do not let you seat out this far and still fit the magazine, but the SWC shapes will.)
