I have read that in all shotshell loads, #1 buckshot produces more potentially effective wound trauma than either #00 or #000 buck.
Also, #1 buck is less likely to over-penetrate and exit an attacker's body. For home defense applications a standard velocity 2¾-inch #1 buck shotshell (16 pellet payload) from Federal, Remington or Winchester is most likely your best choice.
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