There is a certain ergonomics to the gangster grip, if you think about it, in that when you raise your arm, the most relaxed way to do so is to raise it palm down. To turn the hand in another direction requires at least some muscular effort to rotate the elbow and/or the shoulder. If a gun was designed around that fact, it might be ever so slightly advantageous in slow fire, but recoil would be a mess.
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