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Is there a down-side to too much bullet?
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Other than more felt recoil... no...
It is the construction of the bullet that makes it retain original weight... so there is noe meat damage with good retention...
Remember the old timers commonly used 50 caliber muzzle loaders and the meat was precious to them...
Of course they placed their shots quite well so the point may be moot...
But, the .50's didn't explode the head either...
Many elk hunters use large bores like .458's and such... These are limited to a couple hundred yards... but, they anchor the bulls
pooty good!