The two Glocks that I use on a regular basis is my G26/CBST for CCW and my G17/FAS1 Safe for HD. Both are chambered/holstered. I don't leave my chambered guns out of a holster, that way trigger is covered. Since I use two separate guns for both tasks I don't need to take either out of their holsters on a daily basis.
This shows how the holster is mounted in the safe and I think it ads a little extra protection from an AD/ND if I need to grab my gun in the dark and half asleep. This is when I think I would be more susceptible to a AD/ND rather than when carrying.
http://www.youtube.com/watch?v=CcJUGuB35y8
It's easier to grab with my right hand while laying in bed. I usually sleep on my left side.