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A 300wm will kill a Grizzly bear. So will a 3006, a 308, a 35 Whelan, a 9.3x62, etc. As always shot placement trumps caliber and cartridge.
I've taken two grizzlies with a 338wm. Both double lung shots. Both ran about 20 or 30 feet then dropped dead. Works fine but if all I had was a 3006 that shot well I would feel fine about it.
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