The only answer I can give you is...the N-frame Smith & Wesson. Picking a particular model is just personal opinion and the flavor of the day. I regularly shoot these:
This is a customized 1917:
This is a 5" DA 45 Model of 1955:
This is a custom built M25-2 45 ACP "Mountain Gun":
This is the earliest of the 625s, the dash-2 version:
The one I shoot the most is the "Mountain Gun" but I like and shoot them all.
Dave