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What is the inherent danger in reducing loads using H110?
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Possibly a blown up gun. H-110/W296 needs consistent, progressive pressure to burn properly starting with a heavy crimp and heavy bullets. When the charges are reduced too much you get a poor burn and weird pressure spikes.
Also if you are going to be out in cold weather for long periods of time, H-110/W296 is poor choice as it's cold sensitive. You need to use magnum primers or better yet use a powder like Lil'Gun or 4227 for cold weather heavy hitters.