I don't really understand the reason for really heavy bullets in this proposed "quiet gun"... but, I'll play along.
If you are wanting sub-sonic, something that small children can learn with, but can still be loaded "up" to upper sub-sonic levels for hunting (what are you hunting??) you might want to give a thought to the .300 Whisper cartridge. It shoots a .30 caliber bullet (range from 100 to 220 or so?) at subsonic speeds, with some fairly good results on targets.
It also uses WAY less powder to achieve those results than the 45-70, etc, will use. It would probably be similar to the pistol cartridges on powder use.
Suppressing it would be no problem, and I imagine it would suppress more readily than a .45 caliber, but I'm not a physics major, so I could easily be wrong there.
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