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Quite a few bad guys have been known to carry mouseguns. A lot of ugly street crimes/assaults have been carried out with little .22/.25acps. One of the most important aspects of the mousegun, is its concealability. In a self-defense situation, its extreme concealability is likewise the main attribute of its effectiveness.
The range is going to be very close ie. less than 5ft - and maybe less than 1ft. away. Think about 7 shots from a .22 delivered into the torso at a range of about 2ft. Maybe they'll survive? Bullet failure can occur with larger calibres too ie. a .357 mag at close range might miss a vital spot, not open up...and could also be problematic to control via blast/recoil.
There are factual stories of soldiers on the battlefield having
.50cal. rounds go through them...but still living to effectively fight on quite a bit. There's no 'magic bullet.' I'm not saying that the .22/.25acp is the best round - but I would say it can be quite effective. Personally, I prefer a .38, but there are times when a smaller mousegun...is nice to have too. It's not just better than nothing - but a lot better than nothing.
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