I've shot prairie dogs with most of my rifles even my .375 Ruger. One day my BIL and I were shooting them with our .50 caliber Muzzle loaders in preperation for deer season. Patched round ball with 90-95 grains of Pyrodex made the little vermin tumble out to 60 yards or so. Much past there and we were hit or miss with the old front stuffers. I did fill my doe tag that year at 75 yards with my ML.
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