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Ask some of the professional hunters (or read about their exploits) and you'll soon see that while you can kill just about anything on earth with just about any caliber, sometimes being able to do so very fast with very large bullets is the optimal way to go.
If the best mouse trap truly were rounds lik the .375 and .404 Jeffery, then cartridge development for dangerous game would have stopped dead in its tracks as all of the hunters switched over.
That's not what happened, though.
The really big calibers (.500 and up) still have significant followings in Africa as true stopping rifles.
In British parlance, the .416 isn't even a large bore rifle. It's a medium bore.
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