I second FrankenMauser
I've been partial to 00 buck in the past. But a dear friend swears by #4 buckshot. Having recently (last Saturday) patterned the #4 load, I'm quite convinced that it would pretty much ruin any intruder's day, and I have adopted it as my HD load. I know some folks who load #4 with some slugs as follow up rounds. At home defense ranges, the #4 should be more than sufficient unto your needs. In my little humble hovel, frankly, any 12 gauge round is going to do the job, but I have really taken to the #4 load.
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"...A humble and contrite heart, O God, thou wilt not despise." Ps. li
"When law and morality contradict each other, the citizen has the cruel alternative of either losing his moral sense or losing his respect for the law." —Frederic Bastiat
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