I was involved in a serious car accident once, and the injuries left me with some serious physical limitations. Fortunately, my quality of life is good, but I won't last long in a hand-to-hand confrontation.
As such, I've had to change strategies. I have prior training in Aikido (which doesn't place much emphasis on strength), and some of those techniques are viable, but for the most part, I'll be more heavily dependent on a firearm should things go that terribly.
Those three cups of coffee a day do grant me catlike reflexes, however.