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What bullets have you had good experience with in large game hunting?
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I'm not suggesting any of the bullets recommended will not do just fine. I use my 25-06 for deer and antelope. Shots range from 25 yards to 350 yards. I use Sierra 100 gr. Spt. (Sierra stock number 1620) Pro Hunter bullets. I have had excellent results with this bullet on these animals. These aren't really heavy boned and their skin is rather thin. I just haven't seen the benefits of going to a partitioned bullet. If I was going to use my 25-06 for elk, then of course I would go up in weight and a heavier bullet construction.
I do carefully select my bullet location and I don't shoot through shoulders. I very much enjoy eating all the game I take and if you shoot through both shoulders, you are going to lose a lot of meat.
I tend to favor IMR and Hodgdon powders. The Hodgdon website provides excellent data on these powders as well as Winchester.