A rifle takes two hands and room to use. In a house or apartment, you may not have either. Your weak-side hand may be holding a cell phone or flashlight. Rifle bullets, even the little .22, will penetrate a LOT. A pistol is the obvious choice. Select your caliber and round for penetration that will stop within most body cavities.
In a revolver, I'd pick the venerable .38+p in a 4" barrel. For an auto, my choice would be a 9mm+p in a 4" barrel.
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