There are a few .22-243's over here and people have posted some spectacular velocities from them, but the reality seems to be that most down load them to pretty close to 22.250 speeds anyway with a view to barrel life.
One of our local tyros posted chrony figures of 5100 or 5300 (I forget which) primers nowhere to be found... he also had a picture of his barrel which he had sectioned after his final "cook up" it looked like someone had been up there with the TIG welder for the first 12 inches of the barrel
Basically there is only so much powder you can burn in a barrel and going beyond a 22.250 or the AI vesion is getting to the point of no further real returns. Things will go splat - but probably no more than with your current rifle.
I havent tried them yet but the new 53g Vmax has a seriously improved BC for maintaining energy way out there.