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I do think that if he had gotten to knife fighting range that a .22 fired into his ear canal would have been more effective than a knife.
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I agree however getting that precise shot on a moving and biting target is the problem. Then you have entry angles. At that range you are going to be bit more than likely just like with the knife. If a charged up deer can run hundreds of yards after being heart shot by a 30-06 how much damage can a large vicious dog do in the time it takes him bleed out from 22 caliber holes.
Just think about it. Small caliber handgun bullets are slow and light. They lack penetration, the ability to create a large wound channel, and the ability to smash through bone to reach the vitals. They are much more likely to be deflected by the skull and bones.
That leave its users to hope for the perfect shot or the target giving up.