Well-done venison gets tough and strong tasting. On the other hand, medium or medium rare venison is delicious.
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The two worst I am aware of are liver fluke (elk) and wasting disease.
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Out here in the West, flukes are a fact of life. Liver flukes are in the liver and bile ducts. If you don't like worms, don't eat guts. As far as wasting disease "prions" go, cooking won't help.