Number of years back the neighbors boy was over and told of a deer they had shot. "shot it 7 times" is a direct quote. I happen to know his father hunted with a 300 win. mag. Not sure if it was all the 300 or not. The point I am making here is it's where you shoot more than what with.
I don't recommend it but have seen deer killed almost outright with a 222 hit thru the chest.
Recoil as stated above is a individual thing. I think my recommendation would be to shoot what your comfortable with within the acceptable parameters of the game your hunting.
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