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First of all, "leading" is not all bad. A bore will only lead so much and then settle down. So IMO most leading is cosmetic.
Secondly, I've found that the best way to avoid leading is to use a slow powder loaded towards the hot side. And the only way to avoid leading with a fast powder is to reduce the load. So if you were using a slow powder, I would advise you to load it hotter. But since you are using a fast powder I advise that you either ignore the leading or reduce the charge.
Lubes help somewhat, e.g. Lee Liquid Alox will help considerably, but most folks don't like to mess around with a messy lube in the 45acp. I use LLA a lot in revolver loads with great success.
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