If it were legal, I'd consider taking deer with my 22 MAG. Brain shot at distances out to 75 yards or so would be lethal. But I'm a lawful sportsman and will not hunt deer with a banned rimfire cartridge such as 22MAG. It comes down to ethics and sportsmanship.
22MAG hits like a little grenade and kills far better than mere paper charts would suggest. Very deadly on coyotes, turkeys, etc.
Jack
