And I have read the 250 will shoot through a deer and like one fellow said, you can't get more penetration than that. -AL45
I beg to differ. I recently had a 255 gr 45 Colt bullet fail to penetrate the forehead of a rather agitated boar. Seemed to stun him a bit but didn't resolve the situation. Velocity was a rather modest 850 fps or so and the thickness of a boar's skull combined with the angle make this a poor choice of targets but I couldn't talk him into a broadside or ear shot.
A subsequent shot slid around his skull and exited behind his ear, didn't help his disposition much. A third shot between his eyes and he became a bit more compliant.
A new hunting load with a bit heavier and harder bullet is in the works, possibly moving a bit faster as well.