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Of the available options, I'm gonna recommend the .243 with the heavy varmint barrel for your stated uses. Buy it as a barreled action and get yourself a decent stock, like a Bell & Carlson Medalist. Or buy a Boyd's and glass bed it.
I have a Howa .25-06 that I bought as a barreled action. I use it as a hunting rifle, it's sub-MOA with my hand loads but if I were to fire 50 rounds in an hour accuracy would not be so great from the barrel heating up. My three shot groups look a lot better than my five shot groups if I don't give the barrel time to cool. A .25-06 heats up fast, especially in a sporter weight barrel, so nix that idea.
The 6.5x55 is a good option as well but it only comes in a sporter weight barrel and brass will be harder to find/more expensive than .243
Long range bullet selection is great in either .243 or 6.5 but you're gonna need that heavy barrel. Get the .243
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DEO VINDICE
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