It will handle any kind of .38 you can throw at it.
Here's an article that goes into more detail regarding the use of magnums in .357 K-frames.
http://www.gunblast.com/Butch_MagnumLoads.htm
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"And I'm tellin' you son, well it ain't no fun, staring straight down a .44"
-Lynyrd Skynyrd
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