No firearm short of a howitzer is going to always drop an animal instantly. It's just part of hunting. Sometimes you get lucky and get a quick drop with a heart/lung shot and sometimes you've got to track them. Headshots are another matter. As to caliber - pick one of dozens. Bullet selection more than caliber determines meat loss. My person preference is to stick with bullets which hold together in a complete pass-through rather than the ballistic tip types.
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