Yep. Stick powders like Varget don't have the super heavy deterrent coating of a spherical powder, so they don't require a magnum primer to ignite. But if your data was developed with a magnum primer, then you can see some performance difference if you don't use one.
For AR's and other semi-autos, there are military sensitivity primers to reduce the chance of getting a slamfire (though they aren't common in the Armalite mechanism). The CCI #41 is the magnum version of a military sensitivity primer. The Federal GM205MAR is a standard primer with military sensitivity.
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