When it comes to choosing a condition, your psychological comfort is a real factor. However, how well you can actually make use of your weapon under stress in an actual emergency really needs to be a factor. For those who don't know, there is an excellent YouTube channel called "Active Self Protection" that analyzes real footage of those kinds of emergencies. It is well worth spending some time looking at some of those videos, which cover a pretty wide range of events and outcomes. (Obviously, viewer discretion is advised.)
https://www.youtube.com/channel/UCsE...rvF2ImeNWh84mw