I've used Pyrodex, 777, and now BH209 in my NEF muzzle loader with no issues. My manual says with conicals from 250-490 grains use 40-120 grains of loose powder, or up to 150 grains with Pyrodex pellets. I use a 270 grain Areoflite bullet and 90 grains BH209 powder and it gives me a 2" group at 100 yards.
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