TP,
One day I will get off this learning curve and every day is not disappointing. Given that, I really have to ask what is behind this question? Is there a concern? I have shot just about everything there is out of an M/L and this has never come to mind. Can't keep up with all that comes down the pike as to what is shot out of an in-line, nor do I really care to. Have worked up good loads for my use that have met or exceeded all my expectations.
Please excuse me for asking but, Why do you ask this question?? 
Be Safe !!!