It's not up to the Buffalo Bore 340 grain 44 mag +P+ but here are some results with 45 Colt out of a Ruger 7 1/2" Blackhawk: 325 Grain LFN and 325 Grain Hollow point...each loaded to 1100 fps with HP-6 and penetration/expansion evaluated into rubber mulch. The rounds on the right are with 23 grains H-110 at 1300fps (I have loaded to 1400fps but accuracy suffered) Slug on lower left was 158 grain .357 for comparison.
In a Ruger, the 44 can be loaded hotter. To what end? The animal getting hit will be just as dead with either, so long as they are hit in the right place.