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Hello. I've had grand luck with the following load in my No.4 MkII: 150 gr Sierra Spitzer, Frontier cases, Remington 9 1/2M primer/45.0 gr IMR-4895. Cases trimmed to 2.21" and LOA is 3.03" (easy to remember).
This does MOA at 100 yards from my rifle and velocity is about 2600 ft/sec. I suggest that you neck size only to prevent case separation. Since I've been doing that, no separations. Best.
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