Another vote for the .22. When I was living in the country, the little .22 Marlin 60 was the rifle that lived by the back door. For most varmints, I didn't care if they were DRT or if they left under their own steam, but most often a well-placed shot from the .22 did the job.
Nothing wrong with those other calibers, from .243 to .30-06, but for pure varmint control, it's hard to beat a good .22
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