As to bullet stabilization, it will probably not be an issue. You are still getting roughly similar velocities, as .300blk subs usually use fairly quick-burning powder.
Sig already makes a 5.5in barreled .300blk. That said, it will likely run dirtier, as there will be more unburned powder.
PMags with heavy .300blk bullets can be problematic. I had some issues with the Remington UMC 220s. Magpul adjusted the internal dimensions slightly, and now sells a .300blk optimized version of the PMag, if that interests you.
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