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I have killed plenty of deer and antelope with handguns. 357 mags, 44 mags, 44 Spl and 454 Casull.
The 10MM auto beats the 357 in most cases. I am sure you will not have any problem if you shoot well. Any bullet of 180 grains that gives a good wound channel will kill any deer that walks. Cast bullets= LBT style, if your gun will feed them, or any good soft point)
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