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Well, 'duplex' charges were how the 454 Casull started out. The difference is he was willing to blow a gun to bits and start over. He could afford it, didn't care, and figured out how to do it safely.
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He got up to triplex charges, Unique, 2400, and a little Bullseye on top to give a last burst of gas as the bullet moved down the cylinder and barrel and increased the working volume.
Now you can just load it with 296 and do better than ever.
As far as what the manufacturer told Mach II Sailor, they might have been using a special order powder "blend", they more likely were using a bulk powder not sold by the pound, and they were very likely using what they got a good price on this month and will be loading Something Else of similar burn rate next month because they get a better deal.