In my experience with two of them, cast bullets below about 400 grains do not like to go fast. However, they make for amazingly accurate "plinking" loads, if you can call a 350 grain bullet at around 1200 fps a plinker. I use 15-16 grains of Unique with the 350 grainer, and can
consistently put all five rounds into a 4" group @ 100 yards with the stock iron sights. I bought a Weigand Weaver-type base rail and am waiting on a 4x Leupold LER scope to arrive to try to improve on that. H110 and Li'l Gun are the powders of choice for full power loads. H110 may have a slight edge in the velocity dept, but recoil is noticably sharper than with Li'l Gun. I have an NEI mould that casts a 460 grain bullet with my alloy, and I can push it to an honest
1600+ fps out of the 8 3/8" barrel. The lightest bullet I've tried is the 270 grain Barnes, which should be able to hit 2200 fps with max loads. Jacketed 325 grainers can top 2000 fps. Heavy bullets at velocities like this, out of a hangun barrel, is absolutely phenomenal.