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I've killed several deer with the .22-250 using old Nosler solid-based Zipedo bullets, but had a few get away due to deflection of the bullet on smallish branches.
Although I still have a .22-250, I don't use it for deer. After a bad experience, I also don't lend it to people to have them use it for that either. It takes a bit of self-control to limit shots to high-probability kills.
Federal Premium .22-250 factory cartridges with Nosler Partitions are made for medium game such as deer. They probably work pretty well. When deer are hit well with the .22-250, they usually go down very quickly.
Due to the relatively light bullets, shots should be limited to very clear shots at heart, lung and neck, preferably from the side of the animal. Quartering shots and longer frontal shots can be a problem with such light bullets.
Picher
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