2400 used to be regularly recommended for loading .38 Spl., as it was one of the relatively few powders avilable that would work in it.
Sierra and Speer manuals gave loading information for 2400 and .38 Spl. up through the 1960s.
But it's certainly not one of the better choices. As Mal notes, it's too slow.
I'd only consider it with 158-gr. or heavier bullets, a heavy crimp, and an 8 3/8" barrel.
Out of a 2" barrel? Forget it.
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