As a point of reference, my 45 Hunter shoots 2" 5 shot groups at 50 yards.
I would slug the barrel and see if you have a tight spot near the threads. You could also slug the cylinders. The 45 Hunters tend to be a little undersized at the cylinder throats. The other options include trying more ammo types, having someone else shoot it and sending it back to Ruger.
Good luck!
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