I'd be more worried about who's behind anyone unfortunate enough to be the recipient of a well placed .44 Mag. Like Charles Bronson says "Makes a real mess". While I would feel confident with either .44 or .45 I think for home defense I would opt for the .45, especially when you take in to consideration muzzle blast, wall penetration, and probable hearing loss  .
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"Ah ah. I know what you're thinkin'. Did he fire 6 shots or only 5? To tell you the truth in all this excitement I've kind of lost track myself. But with this being a .44 Magnum, the most powerful handgun in the world, and would blow your head clean off... you've got to ask yourself a question. Do I feel lucky? WELL DO YA, PUNK?!!!"- Harry Callahan(Dirty Harry)
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