For deer I'd stick with the 150 grain
For deer I'd stick with the 150 grain at all ranges and figure the extra muzzle velocity a plus.
For bigger game I'd use a bigger bullet. For all around I'm a big fan of the 200 grain in the big .30's for all purposes just as I think the 160 grain is the bullet in the big case 7mm cartridges. Still for 500 yard deer I'd go 150 grain and start it as fast as I could.
I mostly wouldn't shoot at 500 yards even with a laser rangefinder and a self adjusting scope though there is the case of shooting from a bench at notch where the setup has been tested on paper at the actual site in advance of shooting game.
I wouldn't even try for a headshot at extended range. I'd probably be explaining to Clint Rand why I didn't recover a wounded animal and it starved to death with its jaw hanging loose. Missed it by that much.
Knowing the gun and the game is just the beginning.
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