I'm 6'4" and 265lbs. The only really comfortable way for me to carry a decent size gun is OWB. I have found that the Askins Style holster works the best for me. The trailing belt loop seems to pull the butt of the gun close to the body and help prevent printing. It is not a problem for me to carry my 2.5" S&W M66 under a loose fitting shirt using this type of holster. Several makers produce holsters of this type.
http://epsaddlery.com/pc-74-11-doubl...n-holster.aspx
http://www.kramerleather.com/product...&categoryID=24
http://www.donhume.com/products/Prod...m?ProductID=53