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I owned an SR45 and the thumb safety is not an issue. You simply turn the gun in your hand and use the tip of your thumb to put it on, but it sweeps off easily on the draw. And because it’s a “nub” and its positioning, you won’t flip it on by accident when firing.
My problem with the SR was it was not fully reliable even after a trip back to Ruger, so I ditched it.
I tried an American.45 Compact, but found the grip tang shape uncomfortable and the gun in general too bulky and clunky. Felt recoil was also too much for a gun of its bulk and weight. A failed design for Ruger in my opinion.
Of the three you mentioned, the M & P is easily the best choice.
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